The E2F2 Transcription Factor Antibody from MyBioSource.com is a Mouse Monoclonal antibody to E2F2. This antibody recognizes Human antigen. The E2F2 Transcription Factor Antibody has been validated for the following applications: Assay, Electrophoretic Mobility Shift Assay (EMSA), EMSA, Super Shift Assay, and Western Blot.
Description
The E2F family of transcription factors plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1